Dietary energy balance may affect the risk for skin tumor development. Researchers believe that these effects of dietary energy balance are mediated by changes in signaling through the epidermal growth factor receptor (EGFR) and the insulin-like growth factor 1 receptor (IGF-1R). “We have demonstrated that dietary energy balance directly modulates activation of cell surface receptors, specifically the EGFR and the IGF-1R, which subsequently affects signaling through downstream pathways, such as Akt and mTOR. Negative energy balance inhibits, while positive energy balance enhances, signaling through these pathways, thereby modulating cellular growth, proliferation, and survival,” said the lead author of the study.

This post is an original post by ScienceDaily: Skin Care News

Posted: April 13th, 2008 under skin health.
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